Brimonidine Tartrate+timolol+benzalkonium Chloride
About Brimonidine Tartrate+timolol+benzalkonium Chloride
Brimonidine Tartrate+timolol+benzalkonium Chloride is used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye.
Brimonidine Tartrate+timolol+benzalkonium Chloride contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative.
In some cases, Brimonidine Tartrate+timolol+benzalkonium Chloride may cause side effects such as a burning sensation, redness, itching, irritation, and vision disturbances. Most of these side effects do not require medical attention and resolve over time. However, talk to your doctor if the side effects persist or worsen.
Consult a doctor if you are pregnant or breastfeeding. Avoid touching the tip of the dropper as it may contaminate the contents. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.
Uses of Brimonidine Tartrate+timolol+benzalkonium Chloride
Medicinal Benefits
- Brimonidine Tartrate+timolol+benzalkonium Chloride contains Brimonidine tartrate, Timolol, and Benzalkonium chloride, used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension.
- Brimonidine tartrate is an alpha-2 adrenergic receptor agonist that decreases aqueous humour production and increases its drainage.
- Timolol is a beta-blocker that primarily reduces aqueous humour production in the ciliary body.
- Benzalkonium chloride acts as a preservative to maintain the sterility of the solution, ensuring safe and prolonged use.
- Using a fixed-dose combination like Brimonidine Tartrate+timolol+benzalkonium Chloride reduces the number of eye drops needed, improving patient compliance and simplifying treatment regimens.
- By effectively lowering intraocular pressure, Brimonidine Tartrate+timolol+benzalkonium Chloride helps prevent optic nerve damage and supports the long-term preservation of vision in patients at risk of glaucomatous damage.
Directions for Use
- It is recommended to use Brimonidine Tartrate+timolol+benzalkonium Chloride twice daily, approximately 12 hours apart, or as advised by your doctor.
- Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the prescribed number of drops into the pocket. Close your eyes for 1-2 minutes.
- Avoid touching the container tip to the eye or eyelids to prevent contamination.
Storage
Side Effects of Brimonidine Tartrate+timolol+benzalkonium Chloride
- Burning sensation
- Eye redness
- Eye itching
- Irritation
- Vision disturbances
Drug Warnings
- Do not use Brimonidine Tartrate+timolol+benzalkonium Chloride if you are allergic to any of its contents, if you have/had bronchial asthma, severe chronic obstructive bronchitis, low heart rate, heartbeat disorder, heart failure, or if you are taking anti-depressants or monoamine oxidase inhibitors.
- Inform your doctor if you have/had coronary heart disease, slow heartbeat, breathing problems, chronic obstructive pulmonary disease, poor blood circulation disease, diabetes, overactive thyroid, tumour of the adrenal gland, corneal disease, excess acidity in the blood, or kidney or liver problems.
- If you are due to have any surgery or eye surgery, inform the doctor/surgeon that you are using Brimonidine Tartrate+timolol+benzalkonium Chloride.
- Consult your doctor if you are pregnant or breastfeeding.
- Brimonidine Tartrate+timolol+benzalkonium Chloride is not recommended for children below 17 years.
- Brimonidine Tartrate+timolol+benzalkonium Chloride might cause drowsiness, blurred vision; so, drive only if you are alert.
- Let your doctor know if you are taking any other medicines, including herbal products.
Drug Interactions
Drug-Drug Interactions: No interactions found/established.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: No interactions found/established.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is not known if alcohol interacts with Brimonidine Tartrate+timolol+benzalkonium Chloride. Please consult your doctor if you have any concerns.
Pregnancy
cautionPlease consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor if you are breastfeeding. Your doctor will decide if Brimonidine Tartrate+timolol+benzalkonium Chloride can be used by breastfeeding mothers or not.
Driving
cautionBrimonidine Tartrate+timolol+benzalkonium Chloride might cause tiredness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.
Liver
cautionPlease consult your doctor if you have any concerns regarding the usage of Brimonidine Tartrate+timolol+benzalkonium Chloride in patients with liver impairment.
Kidney
cautionPlease consult your doctor if you have any concerns regarding the usage of Brimonidine Tartrate+timolol+benzalkonium Chloride in patients with kidney impairment.
Children
unsafeBrimonidine Tartrate+timolol+benzalkonium Chloride is not recommended for children below 17 years, as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include fresh fruits and vegetables in your diet.
- Avoid smoking and alcohol consumption.
- Avoid intake of baked foods or fried items.
- Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
- Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.
Patients Concern
Disease/Condition Glossary
Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms of glaucoma initially, except the slow loss of vision gradually. However, some symptoms include visible rainbow-coloured circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance or nausea.
Ocular hypertension: It is a condition caused by poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). This leads to a build-up of excess fluid in the eye, resulting in increased pressure inside the eye. If ocular hypertension is not controlled, it may lead to glaucoma.
FAQs
Brimonidine Tartrate+timolol+benzalkonium Chloride is indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension.
Brimonidine Tartrate+timolol+benzalkonium Chloride contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Brimonidine Tartrate+timolol+benzalkonium Chloride helps lower the increased pressure in the eye.
Do not stop using Brimonidine Tartrate+timolol+benzalkonium Chloride without consulting your doctor. Continue using Brimonidine Tartrate+timolol+benzalkonium Chloride for as long as your doctor has prescribed it to you to treat your condition effectually. Consult the doctor if you experience any difficulty while using Brimonidine Tartrate+timolol+benzalkonium Chloride.
Brimonidine Tartrate+timolol+benzalkonium Chloride might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.
Brimonidine Tartrate+timolol+benzalkonium Chloride contains benzalkonium chloride; it might discolour soft contact lenses. Therefore, do not wear contact lens while using Brimonidine Tartrate+timolol+benzalkonium Chloride. Remove contact lenses before using Brimonidine Tartrate+timolol+benzalkonium Chloride and put them back 15 minutes after using Brimonidine Tartrate+timolol+benzalkonium Chloride.
Consult your doctor before using Brimonidine Tartrate+timolol+benzalkonium Chloride if you have hypertension. Regularly monitor blood pressure levels while taking Brimonidine Tartrate+timolol+benzalkonium Chloride to prevent unpleasant events.
Dry mouth could be a side-effect of Brimonidine Tartrate+timolol+benzalkonium Chloride. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Brimonidine Tartrate+timolol+benzalkonium Chloride can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Brimonidine Tartrate+timolol+benzalkonium Chloride and other eye medications.
Consult your doctor before using Brimonidine Tartrate+timolol+benzalkonium Chloride if you are diabetic as Brimonidine Tartrate+timolol+benzalkonium Chloride contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Brimonidine Tartrate+timolol+benzalkonium Chloride is advised.
Brimonidine Tartrate+timolol+benzalkonium Chloride is a highly effective eye drop combination for reducing intraocular pressure (IOP) in glaucoma or ocular hypertension patients. Clinical studies have demonstrated that this combination reduces IOP by 25-30% or more, and its efficacy is superior to either brimonidine or timolol alone. Additionally, Brimonidine Tartrate+timolol+benzalkonium Chloride has a rapid onset of action, with significant IOP reduction observed within 1-2 hours, and its effectiveness is maintained over time with long-term use.
Brimonidine Tartrate+timolol+benzalkonium Chloride should be stored in a cool, dry place at a temperature between 15°C to 30°C (59°F to 86°F). Do not refrigerate or freeze.
Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. If any liquid spills out of your eye, gently blot it away with a clean tissue.
Brimonidine Tartrate+timolol+benzalkonium Chloride should not be stopped when symptoms are relieved, as glaucoma is a chronic condition that requires ongoing management. When Brimonidine Tartrate+timolol+benzalkonium Chloride is stopped, intraocular pressure (IOP) can rise again, potentially leading to vision loss. Therefore, it's essential to continue using Brimonidine Tartrate+timolol+benzalkonium Chloride as directed by your doctor, even if symptoms improve, to maintain control over IOP and prevent long-term damage. However, if your condition is well-controlled and your doctor determines it's safe to do so, they may adjust or discontinue Brimonidine Tartrate+timolol+benzalkonium Chloride to minimize potential side effects and ensure the best possible outcome for your eye health.
Storage: Store Brimonidine Tartrate+timolol+benzalkonium Chloride at room temperature between 15°C and 30°C (59°F and 86°F). Keep the bottle away from direct light and excessive heat. Always replace the cap tightly after use to prevent contamination. Disposal: Do not dispose of unused or expired medication in household trash or wastewater. Follow local regulations for proper medication disposal. Dispose of empty bottles according to local guidelines for medical waste.
Brimonidine Tartrate+timolol+benzalkonium Chloride has several contraindications, including hypersensitivity to its components, reactive airway disease, severe cardiovascular disease, and certain heart conditions. It is also not recommended for neonates, infants, pregnant, or breastfeeding women, unless the benefits outweigh the risks. However, this list is not exhaustive, and it's crucial to consult with your doctor before using this medication. They will evaluate your individual situation and provide personalized guidance on safe use.
